Advances in the application of claudins to tumor therapy / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 931-941, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-771833
ABSTRACT
Claudin proteins are the most crucial components of tight junctions, and play an essential role in maintaining cell polarity, regulating cell permeability and the intercellular ion. In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The expression correlates with tumor prognosis and can serve as a biomarker of prognosis and potential therapeutic targets. This review summarizes the current knowledge regarding claudin dysregulation in cancer and highlights the progress in claudin-based treatments.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Uniones Estrechas
/
Usos Terapéuticos
/
Quimioterapia
/
Enterotoxinas
/
Claudinas
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2019
Tipo del documento:
Artículo
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