Detection of chromosomal abnormalities in abortic tissues derived from patients with recurrent abortions using BoBs technique / 中华医学遗传学杂志

ABSTRACT

OBJECTIVE@#To assess the value of BACs-on-Beads (BoBs) technique for the detection of chromosomal abnormalities in abortus tissues from recurrent pregnancy loss.@*METHODS@#A total of 109 abortus samples were collected and analyzed with the BoBs technique. The incidence and types of chromosomal abnormalities for different age groups and gestational weeks were compared.@*RESULTS@#The BoBs assay has succeeded in all cases, with an incidence for chromosomal abnormalities reaching 62.39% (68/109). The major findings included trisomy 16 (12/68), trisomy 22 (9/68), trisomy 13 (9/68) and trisomy 21 (8/68). The abnormal rate was significantly higher in those above 35-year-old compared with that of the 0.05). The aberration rates were similar for samples derived from second, third and fourth time abortions (P>0.05).@*CONCLUSION@#BoBs technique can detect chromosomal aberrations in miscarriages and may be routinely used for the analysis of early spontaneous abortions.