Structure and function of B-cell linker and its role in the development of B cell-related diseases / 南方医科大学学报
Journal of Southern Medical University
;
(12): 253-256, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-772090
ABSTRACT
B cell linker (BLNK) is a key linker protein of B cell receptor (BCR) signaling pathway. BLNK participates in the regulation of PLC-γactivity and the activation of Ras pathway through its typical structure and interaction network with other proteins, and is thus widely involved in the regulation of B cell proliferation, differentiation, apoptosis and signal transduction. Furthermore, it is closely related to anaphylactic diseases, multiple sclerosis, chromosomal aneuploidy, aneuglobulinemia, B lymphocytic leukemia and lymphoma. Herein we review the structure and biological function of BLNK and its role in B cell-related diseases. BLNK can cooperate with a series of effective proteins to activate BCR signaling pathway, thereby regulating the development, maturation and function of B cells. The functional mutation of BLNK can destroy the homeostasis of B cells and affect the development and maturation of B cells, which leads to the occurrence of B cell related diseases. A comprehensive understanding of the biological functions of BLNK not only provides insights into the pathogenesis of B cell-related diseases, but also inspires new ideas and helps to find breakthroughs for the treatment of these diseases with BLNK as the therapeutic target.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Relación Estructura-Actividad
/
Linfocitos B
/
Receptores de Antígenos de Linfocitos B
/
Transducción de Señal
/
Diferenciación Celular
/
Química
/
Apoptosis
/
Biología Celular
/
Proteínas Adaptadoras Transductoras de Señales
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2019
Tipo del documento:
Artículo
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