Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas / 医学前沿
Frontiers of Medicine
;
(4): 497-508, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-772710
ABSTRACT
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Terapéutica
/
Infecciones Tumorales por Virus
/
Virología
/
Carcinoma
/
Terapia Genética
/
Predisposición Genética a la Enfermedad
/
Usos Terapéuticos
/
Sistemas CRISPR-Cas
/
Edición Génica
Límite:
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2018
Tipo del documento:
Artículo
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