NKT cells in liver diseases / 医学前沿
Frontiers of Medicine
;
(4): 249-261, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-772711
ABSTRACT
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Enfermedades Autoinmunes
/
Alergia e Inmunología
/
Células T Asesinas Naturales
/
Hígado
/
Hepatopatías
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2018
Tipo del documento:
Artículo
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