Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the trace / 医学前沿
Frontiers of Medicine
;
(4): 23-33, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-772731
ABSTRACT
Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunity for microbial genome. Consequently, considerable genetic diversity encoded by bacterial genomes and among the strains in the same species has been revealed. In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resulted in transformation and expedited the application of strategy and methodology for bacterial genome comparison used in dissection of infectious disease epidemics. Bacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirements of epidemiological study in disease control. In this review, we outline the significance and summarize the roles of bacterial genome sequencing in the context of bacterial disease control and prevention.We discuss the applications of bacterial genome sequencing in outbreak detection, source tracing, transmission mode discovery, and new epidemic clone identification. Wide applications of genome sequencing and data sharing in infectious disease surveillance networks will considerably promote outbreak detection and early warning to prevent the dissemination of bacterial diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bacterias
/
Infecciones Bacterianas
/
Vigilancia de la Población
/
Epidemiología
/
Brotes de Enfermedades
/
Técnicas de Tipificación Bacteriana
/
Genoma Bacteriano
/
Secuenciación Completa del Genoma
/
Genética
/
Genotipo
Tipo de estudio:
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2018
Tipo del documento:
Artículo
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