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Applications of RNA Indexes for Precision Oncology in Breast Cancer / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics ; (4): 108-119, 2018.
Artículo en Inglés | WPRIM | ID: wpr-772994
ABSTRACT
Precision oncology aims to offer the most appropriate treatments to cancer patients mainly based on their individual genetic information. Genomics has provided numerous valuable data on driver mutations and risk loci; however, it remains a formidable challenge to transform these data into therapeutic agents. Transcriptomics describes the multifarious expression patterns of both mRNAs and non-coding RNAs (ncRNAs), which facilitates the deciphering of genomic codes. In this review, we take breast cancer as an example to demonstrate the applications of these rich RNA resources in precision medicine exploration. These include the use of mRNA profiles in triple-negative breast cancer (TNBC) subtyping to inform corresponding candidate targeted therapies; current advancements and achievements of high-throughput RNA interference (RNAi) screening technologies in breast cancer; and microRNAs as functional signatures for defining cell identities and regulating the biological activities of breast cancer cells. We summarize the benefits of transcriptomic analyses in breast cancer management and propose that unscrambling the core signaling networks of cancer may be an important task of multiple-omic data integration for precision oncology.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ARN Mensajero / Clasificación / Perfilación de la Expresión Génica / Genómica / MicroARNs / Interferencia de ARN / Medicina de Precisión / Neoplasias de la Mama Triple Negativas / Genética Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Genomics, Proteomics & Bioinformatics Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ARN Mensajero / Clasificación / Perfilación de la Expresión Génica / Genómica / MicroARNs / Interferencia de ARN / Medicina de Precisión / Neoplasias de la Mama Triple Negativas / Genética Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Genomics, Proteomics & Bioinformatics Año: 2018 Tipo del documento: Artículo