Consensus on the detection of microsatellite instability in colorectal cancer and other related solid tumors in China / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 734-741, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-773350
ABSTRACT
Microsatellite instability (MSI) which resulted from the deficiency of DNA mismatch repair (MMR), is an important clinical significance in the related solid tumors, such as colorectal cancer and endometrial cancer. There are several methods to detect MSI status, including immunohistochemistry for MMR protein, multiplex fluorescent polymerase chain reaction (PCR) for microsatellite site and MSI algorithm based on next generation sequencing (NGS). The consensus elaborates the definition and clinical significance of MSI as well as the advantages and disadvantages of the three detection methods. Through this expert consensus, we hope to promote the screening which based on MSI status in malignant tumors and improve the acknowledge of clinicians about various testing methods. Thereby, they could interpret the results more accurately and provide better clinical services to patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Estándares de Referencia
/
Inmunohistoquímica
/
Neoplasias Colorrectales
/
China
/
Reacción en Cadena de la Polimerasa
/
Neoplasias Endometriales
/
Guías de Práctica Clínica como Asunto
/
Repeticiones de Microsatélite
/
Atención a la Salud
Tipo de estudio:
Estudio diagnóstico
/
Guía de Práctica Clínica
Límite:
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2019
Tipo del documento:
Artículo
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