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Role of lipophagy in the regulation of lipid metabolism and the molecular mechanism / 南方医科大学学报
Journal of Southern Medical University ; (12): 867-874, 2019.
Artículo en Chino | WPRIM | ID: wpr-773519
ABSTRACT
Recent studies have discovered a selective autophagy-lipophagy, which can selectively identify and degrade lipids and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. The process of lipophagy can be directly or indirectly regulated by genes, enzymes, transcriptional regulators and other factors. This review examines the role of lipophagy in reducing liver lipid content, regulating pancreatic lipid metabolism, and regulating adipose tissue differentiation, and summarizes the findings of the molecules (Rab GTPase, enzymes, ion channels, transcription factors, small molecular substances) involved in the regulation of lipophagy, which points to new directions for the treatment of diseases caused by lipid accumulation.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Autofagia / Tejido Adiposo / Metabolismo de los Lípidos / Homeostasis / Hígado Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Journal of Southern Medical University Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Autofagia / Tejido Adiposo / Metabolismo de los Lípidos / Homeostasis / Hígado Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Journal of Southern Medical University Año: 2019 Tipo del documento: Artículo