Two new C steroidal glycosides isolated from Cynanchum komarovii / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 610-614, 2018.
Article
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| WPRIM
| ID: wpr-773580
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WPRO
ABSTRACT
The present study was designed to further investigate the C steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC values ranging from 16.6 to 26.3 μmol·L, compared to the positive control 5-fluorouracil (6.4 μmol·L).
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WPRIM
Asunto principal:
Farmacología
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Esteroides
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Medicamentos Herbarios Chinos
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Espectroscopía de Resonancia Magnética
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Estructura Molecular
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Supervivencia Celular
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Química
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Células HL-60
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Cynanchum
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Glicósidos
Límite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2018
Tipo del documento:
Article