A Case of Idiopathic Hypoparathyroidism Associated with Graves' Disease

ABSTRACT

Graves' disease is a relatively rare endocrinologic disorder in childhood age and often associated with other endocrinologic disorders such as type I diabetes mellitus and Addison's disease etc. Also, it is associtated with non-endocrinologic autoimmune diseases such as systemic lupus erythematosus, myasthenia gravis, idiopathic thrombocytopenic purpura, vitiligo and pernicious anemia. However, idiopathic hypoparathyroidism associated with Graves' disease is very rare. Few cases were reported worldwide, but not in Korea. Up to the present, it is well known that some endocrinologic diseases such as Addison's disease, primary hypothyroidism, idiopathic hypoparathyroidism, type I diabetes mellitus and primary gonadal failure occur singlely or more at the same time and this disease entity is called polyglandular autoimmune(PGA) syndrome. We experienced a 14-year-old female child with tingling sensation on extremities and generalized tonic seizure, who had a had history of Graves' disease. We diagnosed her as idiopathic hypoparathyroidism by Brake's criteria. Then, propylthiouracil and vitamin D3 were given and the symptoms and signs subsided. As far as we know, this is the first case of idiopathic hypoparathyroidism with Graves' disease in Korea. So, we report a case of idiopathic hypoparathyroidism associated with Graves' disease with a brief review of related literatures.