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Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 139-142, 2018.
Artículo en Inglés | WPRIM | ID: wpr-773632
ABSTRACT
The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-amine (1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate (2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-yl)acetamide (3). These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells. Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L, respectively.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Extractos Vegetales / Células HeLa / Química / Tallos de la Planta / Pinellia / Tubérculos de la Planta / Proliferación Celular / Alcaloides Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Extractos Vegetales / Células HeLa / Química / Tallos de la Planta / Pinellia / Tubérculos de la Planta / Proliferación Celular / Alcaloides Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2018 Tipo del documento: Artículo