Correlation study on Tibetan medicine Pterocephalus hookeri of bitter taste receptors based on molecular docking technology / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3157-3161, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-773738
ABSTRACT
In order to study the interaction between Pterocephalus hookeri and bitter taste receptors,three-dimensional structural models of bitter taste receptors TAS2 R16,TAS2 R14 and TAS2 R13 were established by homology modeling in this paper. Maestro software was used for docking the chemical constituents of P. hookeri with bitter taste receptors. The results showed that 25 chemical components of P. hookeri can regulate three bitter taste receptors. And these components were mainly iridoid glycosides and phenolic acids.This research focused on the comprehensive application of homology modeling and molecular docking technology to explore the interaction between bitter chemical constituents of P. hookeri and bitter taste receptors. This study provided assistance in revealing pharmacodynamic basis of bitter Tibetan medicine at molecular level. It also provided new ideas and methods for the study of Tibetan medicine.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Gusto
/
Química
/
Caprifoliaceae
/
Medicina Tradicional Tibetana
/
Receptores Acoplados a Proteínas G
/
Simulación del Acoplamiento Molecular
/
Correlación de Datos
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2019
Tipo del documento:
Artículo
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