Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Natural Product Sciences
;
: 293-296, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-7743
ABSTRACT
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 +/- 1.0 microM.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poríferos
/
Comorbilidad
/
Concentración 50 Inhibidora
/
Inflamación
Idioma:
Inglés
Revista:
Natural Product Sciences
Año:
2015
Tipo del documento:
Artículo
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