Research Progress of C-Myc in Chronic Myelogenous Leukemia --Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 297-300, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-774319
ABSTRACT
As a potential target for cancer treatment, the C-Myc high expresses abnormally in a variety of solid tumors and hematological malignancies in humans. In hematologic malignancies, the increasing expression of C-Myc is associated with poor prognosis of patients diffuse large B-cell lymphoma. However, some studies have shown that high expression of C-Myc might be one of the mechanisms of disease progression and abrupt change, therefore, it can promote the transformation of chronic myeloid leukemia. Besides, the high expression of C-Myc may lead to the decrease of the sensitivity of chronic myelogenous leukemia cells to imatinib. Therefore, C-Myc has been concerned in the study of imatinib drug resistance. This review will focuses on the latest research progress on the mechanism of C-Myc in chronic myeloid leukemia in recent years.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Proteínas Proto-Oncogénicas c-myc
/
Linfoma de Células B Grandes Difuso
/
Mesilato de Imatinib
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS