Nucleus translocation of membrane/cytoplasm proteins in tumor cells / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 318-325, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-775217
ABSTRACT
Proteins are the physical basis of life and perform all kinds of life activities. Proteins have different orientations and function in different tissues. The same protein, located in different subcellular regions, can perform different and even opposite functions. Both functional and structural proteins are capable of undergoing re-localization which can directly or indirectly participate in signal transduction. Due to abnormal transduction of signals during carcinogenesis, the proteins originally expressed in the cytoplasm are translocated into the nucleus and lead to functional changes in the tumor tissue. The changes of protein localization are affected by many factors, including the interaction between proteins, expression level of proteins and the cleaved intracellular domain of transmembrane protein.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Transducción de Señal
/
Regulación Neoplásica de la Expresión Génica
/
Núcleo Celular
/
Transporte de Proteínas
/
Citoplasma
/
Línea Celular Tumoral
/
Carcinogénesis
/
Dominios Proteicos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2019
Tipo del documento:
Artículo
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