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Advances in molecular mechanism of vascular remodeling in pulmonary arterial hypertension / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 102-110, 2019.
Artículo en Chino | WPRIM | ID: wpr-775248
ABSTRACT
Pulmonary arterial hypertension (PAH) is a clinical hemodynamic syndrome characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance leading to right heart failure and death. Vascular remodeling is the most prominent histopathological feature of PAH, which is regulated by many factors. Endoplasmic reticulum stress, calcium disorder and mitochondrial dysfunction are involved in the vascular cell proliferation and apoptosis by regulating intracellular calcium homeostasis and cellular metabolism. Epigenetic phenomenon such as DNA damage and abnormal expression of miRNA are also involved in the regulation of abnormal proliferation of vascular cells. Vascular cell phenotype switching including endothelial-mesenchymal transition and smooth muscle cell phenotype switching play an important role in abnormal proliferation of vascular cells. Vascular remodeling is produced by a variety of cells and molecular pathways, and aiming at multiple targets which is expected to find a new breakthrough in the treatment of PAH,and to improve abnormal vascular remodeling, delay or even reverse the progression of PAH.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Arteria Pulmonar / Células Cultivadas / Miocitos del Músculo Liso / MicroARNs / Proliferación Celular / Remodelación Vascular / Genética / Hipertensión Pulmonar Límite: Humanos Idioma: Chino Revista: Journal of Zhejiang University. Medical sciences Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Arteria Pulmonar / Células Cultivadas / Miocitos del Músculo Liso / MicroARNs / Proliferación Celular / Remodelación Vascular / Genética / Hipertensión Pulmonar Límite: Humanos Idioma: Chino Revista: Journal of Zhejiang University. Medical sciences Año: 2019 Tipo del documento: Artículo