Expression of gene and its prognostic value in patients with acute myeloid leukemia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 50-57, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-775254
ABSTRACT
OBJECTIVE@#To investigate the expression of Wilms'tumor 1 () gene in patients with acute myeloid leukemia (AML), and to explore its application in predicting prognosis of AML in patients with wild or mutated nucleophosmin 1() and Fms-like tyrosine kinase 3-internal tandem duplication ().@*METHODS@#One hundred and sixty-seven newly diagnosed AML patients(exclued M3 type) were enrolled in this study. The survival of patients were analyzed with Kaplan-Meier method. The clinical data, laboratory findings and the survival of patients were analyzed and compared between patients with high expression (high- group) and those with low expression (low- group), as well as among the patients with or wild type and mutants.@*RESULTS@#The overall response rates (ORR) in high- and low- groups were 65.9% (83/126) and 95.1% (39/41), respectively (0.05). In patients with wild type, the high- group had inferior ORR and 2-y OS rate (all 0.05).@*CONCLUSIONS@# gene overexpression indicated poor prognosis of AML patients; the patients with decreased gene expression ≥ 1 log after the first induction therapy show better prognosis than those with<1 log. The gene expression level at diagnosis can be used as an unfavorable prognostic factor for AML patients with or wild types.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Proteínas Nucleares
/
Leucemia Mieloide Aguda
/
Mortalidad
/
Supervivencia sin Enfermedad
/
Perfilación de la Expresión Génica
/
Proteínas WT1
/
Diagnóstico
/
Tirosina Quinasa 3 Similar a fms
/
Estimación de Kaplan-Meier
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS