Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 401-418, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-775430
ABSTRACT
Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury coordination data) and inflammatory pain (intraplantar complete Freund's adjuvant both coordination and intensity data) in the DigiGait™ and CatWalk™ systems. DigiGait™ had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk™ excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor
/
Procesamiento de Imagen Asistido por Computador
/
Adyuvante de Freund
/
Ratas Sprague-Dawley
/
Análisis de la Marcha
/
Marcha
/
Analgésicos
/
Inflamación
/
Métodos
/
Neuralgia
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2019
Tipo del documento:
Artículo
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