Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1058-1066, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-775472
ABSTRACT
While inflammatory bowel disease (IBD) might be a risk factor in the development of brain dysfunctions, the underlying mechanisms are largely unknown. Here, mice were treated with 5% dextran sodium sulfate (DSS) in drinking water and sacrificed on day 7. The serum level of IL-6 increased, accompanied by elevation of the IL-6 and TNF-α levels in cortical tissue. However, the endotoxin concentration in plasma and brain of mice with DSS-induced colitis showed a rising trend, but with no significant difference. We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis. These results suggested that DSS-induced colitis increases systemic inflammation which then results in cortical inflammation via up-regulation of serum cytokines. Here, we provide new information on the impact of colitis on the outcomes of cortical inflammation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Polisacáridos
/
Factores de Tiempo
/
Sangre
/
Proteínas de Unión al Calcio
/
Corteza Cerebral
/
Regulación de la Expresión Génica
/
Citocinas
/
Sulfato de Dextran
/
Colitis
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2018
Tipo del documento:
Artículo
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