Expression and Clinical Significance of Cancer-derived Immunoglobulin G in Non-small Cell Lung Cancer by Bioinformatics and Immunohistochemistry / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 341-348, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-775622
ABSTRACT
BACKGROUND@#It was believed that immunoglobulin G (IgG) was synthesized only by B cells. However, in recent years, researchers have found that a variety of cancer cells can also synthesize IgG (cancer-IgG) which promote the development of tumors. This study analyzed the expression and clinical significance of cancer-IgG in non-small cell lung cancer (NSCLC), and initially explored its mechanism.@*METHODS@#The expression of IgG1 heavy chain gamma 1 (IGHG1) and cancer-IgG were detected by bioinformatics and immunohistochemistry in NSCLC; The gene set enrichment analysis (GSEA) method was used to explore the signaling pathways involved in IGHG1 regulation.@*RESULTS@#The expression level of cancer-IgG in NSCLC was significantly higher than that in normal tissues. The high expression group had a poor prognosis and was associated with clinical stage (P=0.042), T stage (P=0.044) and metastasis (P=0.007). GSEA analysis showed that IGHG1 was associated with cell adhesion, cytokine interaction and chemokine signaling pathway.@*CONCLUSIONS@#High expression of cancer-IgG in NSCLC is a poor prognosis factor, which may be related to the promotion of tumor invasion and metastasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Inmunoglobulina G
/
Inmunohistoquímica
/
Proteínas Portadoras
/
Biomarcadores de Tumor
/
Carcinoma de Pulmón de Células no Pequeñas
/
Biología Computacional
/
Genética
/
Neoplasias Pulmonares
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Lung Cancer
Año:
2019
Tipo del documento:
Artículo
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