Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer's Disease / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 248-255, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-776042
ABSTRACT
The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis and degradation,cytoskeletal formation,and cell longevity.Autophagy,a catabolic process necessary for the maintenance of intracellular homeostasis,is essential for cell survival,whereas mTOR is the crucial regulator of autophagy.Alzheimer's disease(AD)is the most common cause of progressive dementia in the elderly.It has been shown that disorders of mTOR and autophagy signaling pathways are closely related to AD.In the present review,we describe the regulatory roles of mTOR signaling and autophagy pathway in AD brain and introduce drugs for AD acting via modulation of autophagy and mTOR.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Autofagia
/
Transducción de Señal
/
Serina-Treonina Quinasas TOR
/
Enfermedad de Alzheimer
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2019
Tipo del documento:
Artículo
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