Bioactive phenazines from an earwig-associated Streptomyces sp / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 475-480, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-776863
ABSTRACT
Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a biosynthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fenazinas
/
Streptomyces
/
Proteínas Bacterianas
/
Espectroscopía de Resonancia Magnética
/
Estructura Molecular
/
Pruebas de Sensibilidad Microbiana
/
Química
/
Familia de Multigenes
/
Micrococcus luteus
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2019
Tipo del documento:
Artículo
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