Withaminimas A-F, six withanolides with potential anti-inflammatory activity from Physalis minima / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 469-474, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-776864
ABSTRACT
Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC values among 3.91-18.46 μmol·L.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Medicamentos Herbarios Chinos
/
Estructura Molecular
/
Química
/
Lipopolisacáridos
/
Physalis
/
Alergia e Inmunología
/
Witanólidos
/
Macrófagos
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2019
Tipo del documento:
Artículo
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