Anti-cancer activities of S-allylmercaptocysteine from aged garlic / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 43-49, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-776905
ABSTRACT
While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine (SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Estructura Molecular
/
Transducción de Señal
/
Química
/
Apoptosis
/
Cisteína
/
Usos Terapéuticos
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Ajo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2019
Tipo del documento:
Artículo
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