AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 527-533, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-777035
ABSTRACT
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Proteínas Tirosina Quinasas
/
Diferenciación Celular
/
Células Cultivadas
/
Oligodendroglía
/
Enfermedades Desmielinizantes
/
Ratas Sprague-Dawley
/
Regulación del Desarrollo de la Expresión Génica
/
Proteína Proteolipídica de la Mielina
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2018
Tipo del documento:
Artículo
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