The Role of Synapsins in Neurological Disorders / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 349-358, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-777051
ABSTRACT
Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication. Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins in maintaining brain physiology. In the recent times, increasing evidence has established the relevance of alterations in synapsins as a major determinant in many neurological disorders. Here, we give a comprehensive description of the diverse roles of the synapsin family and the underlying molecular mechanisms that contribute to several neurological disorders. These physiologically important roles of synapsins associated with neurological disorders are just beginning to be understood. A detailed understanding of the diversified expression of synapsins may serve to strategize novel therapeutic approaches for these debilitating neurological disorders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Enfermedades del Sistema Nervioso Central
/
Sinapsinas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2018
Tipo del documento:
Artículo
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