Modulation of Pain and Itch by Spinal Glia / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 178-185, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-777081
ABSTRACT
Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells. Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Prurito
/
Células Receptoras Sensoriales
/
Médula Espinal
/
Dolor Crónico
/
Metabolismo
/
Neuralgia
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2018
Tipo del documento:
Artículo
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