Modulation of drug-metabolizing enzymes and transporters under hypoxia environment / 生理学报
Acta Physiologica Sinica
;
(6): 336-342, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-777181
ABSTRACT
Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism. Besides, both hypoxia inducible factor 1α (HIF-1α) and microRNA-mediated pathways play a role in regulating drug metabolism. This article reviewed the impact and single-factor modulating mechanisms of drug metabolism under hypoxia, and put forward the speculation and prospects of multi-factor modulating mechanisms.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas de Transporte de Membrana
/
Fisiología
/
Preparaciones Farmacéuticas
/
Hipoxia de la Célula
/
MicroARNs
/
Subunidad alfa del Factor 1 Inducible por Hipoxia
/
Hipoxia
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2019
Tipo del documento:
Artículo
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