Transforming growth factor-β and renal fibrosis / 生理学报
Acta Physiologica Sinica
;
(6): 612-622, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-777223
ABSTRACT
Transforming growth factor-β (TGF-β) is a driving force of renal fibrosis, which may lead to chronic kidney diseases and even end stage renal diseases. By activating canonical and non-canonical signaling pathways, TGF-β promotes the synthesis of extracellular matrix while preventing their degradation. In the injured kidney, TGF-β induces apoptosis, proliferation and fibrotic response of renal cells including epithelial cells, endothelial cells, podocytes, fibroblasts, pericytes and macrophages, and it also promotes transdifferentiation, activation and proliferation of myofibroblasts. Additionally, TGF-β exerts profibrotic effects by interplaying with other signaling pathways like BMP-7, Wnt/β-catenin and MAP kinase. Smad3 is the central pathological gene in renal fibrosis, and epigenetic regulation of TGF-β/Smad3 is a hot topic in kidney field. Although direct targeting TGF-β may cause side effects including tumorigenesis and immune diseases, the therapeutic strategies targeting the balance of downstream Smad3 and Smad7 may prevent or delay the progression of fibrotic kidney disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fibrosis
/
Transducción de Señal
/
Factor de Crecimiento Transformador beta
/
Epigénesis Genética
/
Proteína smad7
/
Proteína smad3
/
Enfermedades Renales
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2018
Tipo del documento:
Artículo
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