Vertical transmission of hepatitis B virus: Modes and blocking strategies / 临床肝胆病杂志

ABSTRACT

Mother-to-child vertical transmission is the main mode of transmission of chronic hepatitis B in China. The probability of failure in blocking vertical transmission is about 10% in pregnant mothers with a high viral load, and therefore, correct management of hepatitis B virus (HBV) is of great importance during pregnancy. In addition, viral treatment during pregnancy should take into account the risk of vertical transmission, the health of pregnant women, and the safety of fetus, and each treatment method or prevention option needs to be carefully evaluated. Reasonable antiviral methods, drug selection, and drug withdrawal time can reduce the probability of mother-to-child transmission. This article summarizes the modes of mother-to-child vertical transmission of chronic hepatitis B and related blocking strategies, so as to provide a reference for improving the blocking rate of vertical transmission of HBV.