Research advances in traditional Chinese medicine regulation of autophagy in treatment of liver cancer / 临床肝胆病杂志

ABSTRACT

Autophagy has become a research hotspot in the prevention and treatment of tumor in recent years. With the help of the bidirectional regulatory effect of autophagy, it can not only provide energy and a stable internal environment for normal and tumor cells by clearing misfolded proteins and damaged organelles in cells, but also induce autophagic death of tumor cells. Traditional Chinese medicine has advantages over Western medicine in better mediating autophagy to inhibit tumor development and progression, with the features of low toxicity, multiple targets, and multiple pathways. With an increasing number of studies on autophagy in traditional Chinese medicine, this article reviews the research advances in the effect of traditional Chinese medicine in autophagy in liver cancer in the past 10 years and explores and analyzes existing problems, hoping to provide a reference and new ideas for subsequent research on liver cancer.