Role of Toll-like receptors in development and progression of nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

The pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear. Many studies have shown that Toll-like receptors are involved in the development and progression of NAFLD, especially nonalcoholic steatohepatitis. This article reviews the role of Toll-like receptors in the pathogenesis of NAFLD from three aspects interactions between Toll-like receptors and inflammatory factors, interactions between Toll-like receptors and free fatty acids, and Toll-like receptor gene polymorphism.