Diagnostic value of H19 gene in hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

Recent studies have shown that some long non-coding RNAs (lncRNAs) are expressed abnormally in hepatocellular carcinoma (HCC) tissue, and the expression of H19 gene in lncRNAs in HCC tissue is significantly higher than that in normal tissue. After the knockout of H19 gene, the proliferative and invasive abilities of HCC are significantly reduced. This article briefly introduces lncRNAs and H19 gene, the detection method for lncRNAs, and the value of H19 in the diagnosis of HCC and points out that H19 may be used in a method for the diagnosis of HCC. Further studies on the expression of H19 in HCC and rapid, simple, and economic detection of lncRNAs including H19 play important roles in the diagnosis of HCC.