Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury / 临床肝胆病杂志

ABSTRACT

Hepatic ischemia-reperfusion injury (HIRI) is a process caused by the combined effect of various factors, and to some extent, it limits the development of liver surgery. In-depth studies on mechanisms of HIRI and the development of reasonable therapeutic strategies have positive effects on the prognosis of patients. This article introduces the pathogenesis of HIRI, including calcium overload, Kupffer cells, microcirculation disturbance, production of reactive oxygen species, complement, non-coding RNA, and various cytokines, and the combined effect of these factors induces the necrosis and apoptosis of hepatocytes. In addition, as a second mode of cell death, autophagy is also involved in HIRI. Due to the complex mechanism of HIRI and many factors involved, intervention should be given from various aspects. This article points out that with the development of intervention such as ischemic pretreatment, mild hypothermia and hydrogen, the new therapeutic methods are expected to bring new thoughts to the clinical intervention of HIRI.