Effect of laparoscopic cholecystectomy on aminotransferase levels in patients with hyperlipidemia / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate the effect of laparoscopic cholecystectomy (LC) on postoperative levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with different types of hyperlipidemia (HLP). MethodsA total of 213 HLP patients who underwent LC in Department of Hepatobiliary Surgery in Air Force General Hospital, PLA from January 2012 to December 2014 were analyzed retrospectively, and according to the serum levels of total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol(HDL), they were divided into high TC group (n=63), high TG group (n=53), and mixed group (n=48), low HDL group(n=49). The patients with normal blood lipid who underwent LC during the same period of time were enrolled as non-HLP group (n=204). Enzyme-linked immunosorbent assay was performed before surgery and on days 1, 3, and 7 after surgery to measure the levels of ALT and AST. Analysis of variance was used for comparison of continuous data between several groups, and q-test was used for comparison of such data between each two groups; the chi-square test was applied for comparison of categorical data between groups. ResultsAll the HLP groups had significantly higher levels of aminotransferases before surgery than the normal control group (all P＜0.05), and the high TC group had significantly greater increases in ALT and AST levels compared with the other HLP groups (all P＜0.05). Compared with the control group, all the HLP groups had varying degrees of increase in ALT and AST levels on days 1 and 3 after LC, and the high TC group had significantly greater increases in ALT and AST levels compared with the other HLP groups (all P＜0.05). In all the groups, the levels of aminotransferases on day 7 after surgery returned to normal, with no occurrence of severe abnormal liver function. ConclusionLC has a little influence on the liver in HLP patients. Clinical observation should be performed, and the treatment to protect the liver and reduce the levels of aminotransferases should be given when necessary.