Design, synthesis and biological evaluation of inhibitors of urate transporter 1 (URAT1) / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1069-1074, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-780183
ABSTRACT
Urate transporter 1 (URAT1) is a validated target for the treatment of hyperuricemia. Based on the structure of URC-102, which is currently under a phase Ⅱ clinical trial, fourteen novel analogs were designed and synthesized. Among them, four compounds (9b, 9c, 10e and 10g) exhibited substantial inhibitory effect against URAT1. The most active compound 9b showed an IC50 value of 0.061 μmol·L-1, which is significantly more potent than Lesinurad and Benzbromarone. Preliminary SAR was drawn, providing clues for further structural optimization.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS