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Exploration of non-clinical pharmacodynamics evaluation system of amyotrophic lateral sclerosis / 药学学报
Acta Pharmaceutica Sinica ; (12): 788-800, 2019.
Artículo en Chino | WPRIM | ID: wpr-780197
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is among the most common type of motor neuron diseases, and its pathogenesis remains unclear. In recent years, our understanding of the genetic basis of ALS has led to the development of various ALS disease models, which allow for screening of ALS-related drugs and treatment methods. This review focuses on the research progress of ALS, summarizes the systems of commonly used experimental animal models, including transgenic animals, gene knockout approaches and autonomous animal models, points to the problems needing attention in standardized ALS non-clinical research, and proposes the criteria for selection of standardized R&D model.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2019 Tipo del documento: Artículo