Prevalence and Clinical Outcome of Penicillin-resistant Pneumococcal Pneumonia / 결핵
Tuberculosis and Respiratory Diseases
;
: 295-303, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-78022
ABSTRACT
BACKGROUND:
The incidence of penicillin-resistant streptococcus pneumoniae(PRSP) accounts for almost 70% of all pneumococcal pneumonia cases in Korea. It is still unclear as to whether the efficacy of penicillin or equally active beta-lactam agents is compromised in PRSP pneumonia. This study investigated the prevalence of PRSP in community-acquired pneumonia and its clinical course.METHODS:
A total of 42 patients with community-acquired pneumococcal pneumonia were evaluated from July 1999 to May 2001. The cultured strains of Streptococcus pneumoniae were divided into susceptible, intermediately resistant, and resistant strains by an E-test, and the effect of the clinical course was investigated.RESULTS:
From a total of 42 patients, 22 (52.4%) patients had an intermediate resistance (MIC 0.1-1 microgram/ml) and six (14.3%) showed a high resistance (MIC> or =2.0 microgram/ml) with current penicillin susceptibility categories. However, according to the classification of the DRSPTWG (Drug Resistant Streptococcus pneumoniae Therapeutic Working Group), there were 11 cases (26.2%) of intermediate resistance and no case of high resistance. Under empirical antimicrobial treatment, there was no difference in the clinical outcome between the penicillin susceptible and resistant group.CONCLUSION:
The clinical outcome of PRSP pneumonia with empirical therapy was acceptable. These results suggest that the current MIC breakpoint for penicillin resistance in Streptococcus pneumoniae has been set at a very low level and penicillin resistance according to the NCCLS classification does not significantly influence the outcome of the empirical treatment for pneumococcal pneumonia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Penicilinas
/
Neumonía
/
Neumonía Neumocócica
/
Pronóstico
/
Streptococcus
/
Streptococcus pneumoniae
/
Resistencia a las Penicilinas
/
Incidencia
/
Prevalencia
/
Clasificación
Tipo de estudio:
Estudio de incidencia
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Año:
2003
Tipo del documento:
Artículo
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