Genetic study of a pedigree affected with oculodentodigital dysplasia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 1191-1194, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-781319
ABSTRACT
OBJECTIVE@#To explore the genetic basis of a pedigree affected with oculodentodigital dysplasia.@*METHODS@#Genomic DNA was extracted from peripheral blood or amniotic fluid samples derived from the pedigree. Exon 2 of the GJA1 gene was amplified for sequencing.@*RESULTS@#Two pedigree members were found to carry heterozygous missense variation of the GJA1 gene, c.221A>C (p.H74P).@*CONCLUSION@#The missense c.221A>C variation of the GJA1 gene probably underlies the oculodentodigital dysplasia in this pedigree.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linaje
/
Anomalías Dentarias
/
Deformidades Congénitas del Pie
/
Anomalías del Ojo
/
Conexina 43
/
Sindactilia
/
Anomalías Craneofaciales
/
Genética
/
Mutación
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2019
Tipo del documento:
Artículo
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