Correlation of Peripheral Blood T Lymphocyte Subsets with Prognosis of Elderly Patients with Newly Diagnosed Multiple Myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1876-1880, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-781525
ABSTRACT
OBJECTIVE@#To investigate the expression level of T lymphocyte subsets in elderly patients with newly diagnosed multiple myeloma (NDMM), and to evaluated the prognostic value of T lymphocytic abnormalities in elderly NDMM patients.@*METHODS@#Pretreated peripheral blood of 39 newly diagnosed elder patients with MM was tested by multi-parameter flow cytometry (MFC) to quantitatively detect T lymphocyte subsets, including CD4T cell, CD8T cell, and CD4/CD8 ratio. The prognostic values T-lymphocyte subset were evaluated in newly diagnosed elderly patients with MM.@*RESULTS@#The median follow-up time was 21.5 (range, 3.0-66.0) months. Absolute counts of CD4T cell and CD4/CD8 ratio positively correlated with prognosis. In the multivariate COX analysis, lower CD4/CD8 ratio and CD4T cell counts were identified to be independent adverse prognostic factors for OS.@*CONCLUSION@#Lower CD4/CD8 ratio and CD4T cell counts at initial diagnosis are independent unfavorable prognostic factors for elderly patients with MM, and T lymphocyte subsets are crucial indicators for MM patients' prognosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Subgrupos Linfocitarios
/
Subgrupos de Linfocitos T
/
Relación CD4-CD8
/
Recuento de Linfocitos
/
Citometría de Flujo
/
Mieloma Múltiple
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Anciano
/
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS