An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 108-116, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-78353
ABSTRACT
PURPOSE:
The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population. MATERIALS ANDMETHODS:
A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.RESULTS:
Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.CONCLUSION:
JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Haplotipos
/
Proteínas Tirosina Quinasas
/
Modelos Logísticos
/
Regiones Promotoras Genéticas
/
Quinasas Janus
/
Janus Quinasa 3
/
Corea (Geográfico)
/
Pulmón
/
Neoplasias Pulmonares
Tipo de estudio:
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2011
Tipo del documento:
Artículo
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