Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
The Korean Journal of Internal Medicine
;
: 285-293, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-78395
ABSTRACT
BACKGROUND/AIMS:
The objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status.METHODS:
The study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status.RESULTS:
Analysis of premenopausal women showed no significant differences in the homeostasis model of assessment-insulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.CONCLUSIONS:
Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resistencia a la Insulina
/
Cálculos Biliares
/
Distribución de Chi-Cuadrado
/
Modelos Logísticos
/
Oportunidad Relativa
/
Encuestas y Cuestionarios
/
Factores de Riesgo
/
Factores de Edad
/
Posmenopausia
/
Medición de Riesgo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
The Korean Journal of Internal Medicine
Año:
2011
Tipo del documento:
Artículo
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