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Successful engraftment after infusion of multiple low doses of CD34+ cells from a poorly matched sibling donor in a patient with severe aplastic anemia / 영남의대학술지
Yeungnam University Journal of Medicine ; : 148-151, 2019.
Artículo en Inglés | WPRIM | ID: wpr-785307
ABSTRACT
The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that 2×10⁶ CD34+ cells/kg is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was 15.9×10⁸ cells/kg and 0.95×10⁶ cells/kg, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Células Madre / Donantes de Tejidos / Trasplante Homólogo / Trasplante de Células Madre Hematopoyéticas / Trasplante de Células Madre de Sangre del Cordón Umbilical / Trasplante de Células Madre de Sangre Periférica / Hermanos / Parto / Sangre Fetal / Anemia Aplásica Límite: Humanos Idioma: Inglés Revista: Yeungnam University Journal of Medicine Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Células Madre / Donantes de Tejidos / Trasplante Homólogo / Trasplante de Células Madre Hematopoyéticas / Trasplante de Células Madre de Sangre del Cordón Umbilical / Trasplante de Células Madre de Sangre Periférica / Hermanos / Parto / Sangre Fetal / Anemia Aplásica Límite: Humanos Idioma: Inglés Revista: Yeungnam University Journal of Medicine Año: 2019 Tipo del documento: Artículo