Phenotypes and endotypes of atopic dermatitis: Clinical implications
Allergy, Asthma & Respiratory Disease
;
: 9-14, 2020.
Artículo
en Coreano
| WPRIM
| ID: wpr-785353
ABSTRACT
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, characterized by a complex pathophysiology and a variety of clinical phenotypes. However, heterogeneous clinical phenotypes are generally not considered in treating AD. To date, phenotypes and endotypes have been proposed to classify AD mainly based on differences in age, IgE, severity, race, skin barrier dysfunction, immune (Th2/Th17/Th22) polarization, and skin microbiome. Various biologics to target polarized immune pathways, including dupilumab, have been newly developed for the personalized treatment of moderate-to-severe AD. Further understanding of AD pathophysiology and identification of novel biomarkers will not only allow clinically useful stratification of AD and but also achieve precision medicine for the prevention and treatment of AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Piel
/
Enfermedades de la Piel
/
Productos Biológicos
/
Inmunoglobulina E
/
Biomarcadores
/
Grupos Raciales
/
Dermatitis Atópica
/
Medicina de Precisión
/
Microbiota
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Allergy, Asthma & Respiratory Disease
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS