A Case of Sclerodermatous Chronic Graft versus Host Disease Associated with Cicatricial Alopecia / 대한피부과학회지

ABSTRACT

Cutaneous chronic graft versus host disease (GVHD) has been classified into lichenoid and scleroderma-like forms. However, some atypical cutaneous manifestation may be prevalent. A 9-year-old boy was diagnosed with acute lymphoblastic leukemia in March 2004 and underwent unrelated matched bone marrow transplantation (uBMT) in February 2005. However, one month after transplantation, he started suffering from acute GVHD. After clinical recovery, extensive sclerotic patch or plaque with alopecia developed. The scalp biopsy showed atrophy of the epidermis, inflammatory cell infiltration and sclerosis in the dermis which were consistent with cicatricial alopecia. We report a case of sclerodermatous chronic cutaneous GVHD showing cicatricial alopecia.