Autophagy, Cellular Aging and Age-related Human Diseases
Experimental Neurobiology
;
: 643-657, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-785792
ABSTRACT
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Autofagia
/
Daño del ADN
/
Envejecimiento
/
Orgánulos
/
Senescencia Celular
/
Estrés Oxidativo
/
Enfermedades Neurodegenerativas
/
Acortamiento del Telómero
/
Homeostasis
/
Longevidad
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2019
Tipo del documento:
Artículo
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