Ceramides: Nutrient Signals that Drive Hepatosteatosis
Journal of Lipid and Atherosclerosis
;
: 50-65, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-786082
ABSTRACT
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte have been met and its storage capacity is full, such that free fatty acids start to couple to the sphingoid backbone rather than the glycerol moiety that is the scaffold for glycerolipids (e.g., triglycerides) or the carnitine moiety that shunts them into mitochondria. As ceramides accrue, they initiate actions that protect cells from acute increases in detergent-like fatty acids; for example, they alter cellular substrate preference from glucose to lipids and they enhance triglyceride storage. When prolonged, these ceramide actions cause insulin resistance and hepatic steatosis, 2 of the underlying drivers of cardiometabolic diseases. Herein the author discusses the mechanisms linking ceramides to the development of insulin resistance, hepatosteatosis and resultant cardiometabolic disorders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Triglicéridos
/
Resistencia a la Insulina
/
Carnitina
/
Ceramidas
/
Hepatocitos
/
Ácidos Grasos
/
Ácidos Grasos no Esterificados
/
Hígado Graso
/
Enfermedad del Hígado Graso no Alcohólico
/
Glucosa
Idioma:
Inglés
Revista:
Journal of Lipid and Atherosclerosis
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS