Therapeutic Angiogenesis with Somatic Stem Cell Transplantation
Korean Circulation Journal
;
: 12-21, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-786216
ABSTRACT
Therapeutic angiogenesis is an important strategy to rescue ischemic tissues in patients with critical limb ischemia having no other treatment option such as endovascular angioplasty or bypass surgery. Studies indicated so far possibilities of therapeutic angiogenesis using autologous bone marrow mononuclear cells, CD34⁺ cells, peripheral blood mononuclear cells, adipose-derived stem/progenitor cells, and etc. Recent studies indicated that subcutaneous adipose tissue contains stem/progenitor cells that can give rise to several mesenchymal lineage cells. Moreover, these mesenchymal progenitor cells release a variety of angiogenic growth factors including vascular endothelial growth factor, fibroblast growth factor, hepatocyte growth factor and chemokine stromal cell-derived factor-1. Subcutaneous adipose tissues can be harvested by less invasive technique. These biological properties of adipose-derived regenerative cells (ADRCs) implicate that autologous subcutaneous adipose tissue would be a useful cell source for therapeutic angiogenesis in humans. In this review, I would like to discuss biological properties and future perspective of ADRCs-mediated therapeutic angiogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Médula Ósea
/
Factor de Crecimiento de Hepatocito
/
Angioplastia
/
Péptidos y Proteínas de Señalización Intercelular
/
Trasplante de Células Madre
/
Factor A de Crecimiento Endotelial Vascular
/
Grasa Subcutánea
/
Extremidades
/
Células Madre Mesenquimatosas
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Circulation Journal
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS