Treatment Response Assessment of Skeletal Metastases in Prostate Cancer with ¹⁸F-NaF PET/CT / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
; : 247-252, 2019.
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| WPRIM
| ID: wpr-786484
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To determine the utility of ¹⁸F-sodium fluoride positron emission tomography-computed tomography (¹⁸F-NaF PET/CT) in the imaging assessment of therapy response in men with osseous-only metastatic prostate cancer.METHODS: In this Institutional Review Board-approved single institution retrospective investigation, we evaluated 21 ¹⁸F-NaF PET/CTscans performed in 14 patients with osseous metastatic disease from prostate cancer and no evidence of locally recurrent or soft-tissue metastatic disease who received chemohormonal therapy. Imaging-based qualitative and semi-quantitative parameters were defined and compared with changes in serum PSA level.RESULTS: Qualitative and semi-quantitative image-based assessments demonstrated > 80% concordance with good correlation (SUV(max) κ = 0.71, SUVavg κ = 0.62, SUVsum κ = 0.62). Moderate correlation (κ = 0.43) was found between SUV(max) and PSA-based treatment response assessments. There was no statistically significant correlation between PSA-based disease progression and semi-quantitative parameters. Qualitative imaging assessment was moderately correlated (κ = 0.52) with PSA in distinguishing responders and non-responders.CONCLUSION: ¹⁸F-NaF PET/CT is complementary to biochemical monitoring in patients with bone-only metastases from prostate cancer which can be helpful in subsequent treatment management decisions.
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Asunto principal:
Próstata
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Neoplasias de la Próstata
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Estudios Retrospectivos
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Progresión de la Enfermedad
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Electrones
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Fluoruros
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Tomografía Computarizada por Tomografía de Emisión de Positrones
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Metástasis de la Neoplasia
Tipo de estudio:
Observational_studies
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Qualitative_research
Límite:
Humans
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Male
Idioma:
En
Revista:
Korean Journal of Nuclear Medicine
Año:
2019
Tipo del documento:
Article